“To a solution of 3.0 g 5-methoxytryptamine in 20 mL sulfolane (tetramethylenesulfone) there was added 8.2 g diisopropylethyl amine and 10.7 g 2-iodopropane, and the two-phase mixture was heated on the steam bath with frequent shaking. After 3 h, the mixture was brought back to room temperature and stirred vigorously for an additional 16 h. After the removal of all volatiles under vacuum, the residue (30 g) was diluted with 100 ml H2O, which gave a clear solution. . . .” (Shulgin & Shuulgin, 2003)

Many analogs of a class of tryptamines are hallucinogenic substances that exist naturally in some plants, fungi, and animals, but also can be produced synthetically. These hallucinogens have been placed in Schedule I of the CSA (Controlled Substances Act of 1970). They include psilocybin, psilocyn, bufotenine, alpha-ethyltryptamine, diethyltryptamine, and dimethyltryptamine (DEA Intelligence Brief, 2003). On April 4, 2003, both 5-MeO-Dipt and AMT were placed into Schedule I through an emergency scheduling procedure. Both are now illegal to buy, possess, or sell without a DEA license.

Hallucinogenic Tryptamines

• psilocybin (O-phosphoryl-4-hydroxy-N, N-ethyltryptamine)
• psilocyn (4-hydroxy-N, N-dimethyltryptamine)
• bufotenine (5-hydroxy-N, N-dimethyltryptamine)
• alpha-ethyltryptamine (AET)
• diethyltryptamine (DET)
• dimethyltryptamine (DMT)
• alpha-methyltryptamine (AMT)
• 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT)
• 5-methoxy-N, N-diisopropyltryptamine (5-MeO-DIPT) — “Foxy”

The behavioral effects of orally administered AMT (20 mg) are slow in onset, occurring after 3 to 4 hours. These effects gradually subside after 12 to 24 hours, but may last up to two days. The majority of users report nervous tension, restlessness, inability to sleep, and blurry vision. A 20 mg dose of AMT may be equal in effect to approximately 50 micrograms of lysergic acid diethylamide (LSD). AMT also produces hallucinations and amphetamine-like mood-elevating effects.

5-MeO-DIPT also produces pharmacological effects similar to other Schedule I hallucinogens such as DMT. Following oral administration of 6-10 mg, 5-MeO-DIPT produces subjective effects with an onset at about 20-30 minutes, a peak at about 1-1.5 hours and duration of about 3 to 6 hours. “Foxy” or “Foxy Methoxy” users are talkative and disinhibited. High doses of 5-MeO-DIPT produce nausea, muscle tension and hallucinations of both the auditory and visual variety (DEA Notice of Intent, 2003).

Users of tryptamines experience various effects including hallucinations, euphoria, dilated pupils, empathy, visual and auditory disturbances/distortions, “feelings of love,” and emotional distress. Tryptamines, like “Foxy” and AMT, are very dose dependent, which means that the doubling of a moderate dose could result in effects similar to LSD. The feelings of closeness, love, connection, and empathy seem to be the most desired effects. For some, the higher dose LSD-like effects are the goal. This pattern seems to be consistent with users of MDMA (“Ecstasy”) and other hallucinogens. Both “Foxy” and AMT are becoming a part of the “rave” and club scene.

“Foxy” is often found in tablet and capsule form. The capsules usually contain a powder that is blue, green, tan, orange, pink, or gray in color. Tablets containing “Foxy” have been purple in color and embossed with a logo such as a spider or alien head. “Foxy” tablets analyzed by DEA laboratories have been red and purple. AMT is also found in tablet and capsule form and contains either an orange or off-white powder.

At this time, there is no blood, urine, saliva, or hair sample test for either AMT or 5-MeO-DIPT. One of the standard tests know as the NIDA 5 tests only for cannabinoids, cocaine, amphetamines, opiates, and phencyclidine. Expanded tests may include barbiturates, methaqualone, benzodiazepines, MDMA, hallucinogens, inhalants, methadone, and propoxyphene (Drug Testing Basics, 2003).

There are numerous sources of information about “Foxy” and AMT on the Internet. Some — as in the first paragraph of this report — tell how to manufacture these substances. Others describe personal experiences of those who have used. Erowid.org is such a site and offers a MeO-DIPT User’s Guide by an author named Loosenut (MeO-DIPT User’s Guide, 2003). It could be that this person has used just a little too much of the product described in the article.

Cardwell C. Nuckols, PhD, is President of Cardwell C. Nuckols & Assoc., LLC a national and international training and consulting organization. He can be reached at This e-mail address is being protected from spam bots, you need JavaScript enabled to view it

References
DEA Intelligence Brief. (2003). http://www.usdoj.gov/dea/pubs/intel/02052/02052.html
DEA Notice of Intent to Schedule Alpha-methyltryptamine and 5methoxy-Ndiisopropyltryptamine. (2003). http://www.cognitiveliberty.org/dll/amt_5meo-dipt_Dea_notice.htm.
Drug Testing Basics. (2003). From Erowid. http://www.erowid.org/psychoactives/testing/testing_info1.shtml.
Me-O-DIPT User’s Guide. (2003). From Erowid. http://www.erowid.org/chemicals/5meo_dipt/5meo_diptguide.shtml.
Shulgin, A. & Shulgin, A. (2003). From Erowid online text Tihkal. http://www.erowid.org/library/books_online/tihkal/tihkal37.shtml.

This article is published in Counselor,The Magazine for Addiction Professionals, August 2003, v.4, n.4, pp. 42-43.

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